Pioglitazone Side Effects. Call your doctor if you have any unusual problems while you are taking this medication. Stop using pioglitazone and call your doctor at once if you have symptoms of liver damage.
Nausea upper stomach pain itching loss of appetite dark urine clay-colored stools or jaundice yellowing of the skin or eyes. Generic Actos is not available in the US but is available in other countries as pioglitazone. Actos pioglitazone is a diabetes drug prescribed alongside diet and exercise to control blood sugar levels in people with Type 2 diabetes.
Side effects include weight gain and hypoglycemia.
The most common side effect is low blood sugar. The most common side effect is low blood sugar. Metformin may affect the absorption of vitamin B-12. Side effects not requiring immediate medical attention.