Lorazepam Metabolites. For example lorazepam and 7-aminoclonazepam the primary metabolite of clonazepam have limited cross-reactivity with traditional IAs due to their molecular structures. There are no major active metabolites.
It is metabolised by a simple one-step process to a pharmacologically inert glucuronide. The drug is metabolized primarily by the liver and then eliminated from the. Not to exceed dose of 4 mg.
Alternatively 01 mgkg at slow IV rate not to exceed rate of 2 mgmin.
Poisons A and. Benzodiazepines are extensively metabolized and the parent compounds are not detected in urine. Lorazepam glucuronide is an inactive metabolite and is eliminated mainly by the kidneys. The elimination half-life is about 12 hours and there is minimal risk of excessive accumulation.