Hydroxychloroquine Mechanism Of Action Lupus. Hydroxychloroquine on the other hand is a very mild immunomodulatory agent that inhibits intracellular toll-like receptor TLR9. Alone and in combination with many other drugs 5 6.
13 It is a commonly prescribed medication in the treatment of uncomplicated malaria rheumatoid arthritis chronic discoid lupus erythematosus and systemic lupus. Hydroxychloroquine is a antimalarial medication antirheumatic. These compounds lead to improvement of clinical and laboratory parameters but their slow onset of action distinguishes them from glucocorticoi.
Some argue that hydroxychloroquine raises the pH levels of the host cells attacked by the virus thus preventing the virus from releasing its genes and replicate.
Generic Name Hydroxychloroquine DrugBank Accession Number DB01611 Background. Regardless of the antiviral drug dexamethasone has proved little relief against COVID-19. Hydroxychloroquine Plaquenil and its sister drug chloroquine are under investigation for treatment of the COVID-19 coronavirus disease. Anti-malarial drug hydroxychloroquine has demonstrated more promising results against COVID-19 and it is used in higher frequency.