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Accutane is an effective medication for treating acne but can have concerning side effects. Accutane is an effective medication for treating acne but can have concerning side effects. Data sources include IBM Watson Micromedex updated 3 May 2021 Cerner Multum updated 4 May 2021. Doxycycline has no known interaction with antiretroviral agents but concurrent use may lead to increased levels of calcineurin inhibitors and mTOR inhibitors sirolimus.