Clopidogrel Loading Dose. CYP2C19 poor metabolizers associated with diminished antiplatelet response to clopidogrel. A randomized comparison of high clopidogrel loading doses in patients with non-ST-segment elevation acute coronary syndromes.
It is also used together with aspirin in heart attacks and following the placement of a coronary artery stent dual antiplatelet therapy. 9 Clopidogrel can be taken with or without food. Usual Adult Dose for Acute Coronary Syndrome.
Secondary outcome measures are changes in biomarkers of platelet and endothelial function and their.
Secondary outcome measures are changes in biomarkers of platelet and endothelial function and their. Participants receive a single 600-mg clopidogrel loading dose phase I followed by a daily 75-mg clopidogrel maintenance dose over 28 days phase II. The researchers randomly assigned 128 NSTEACS patients 11 to clopidogrel 600-mg loading dose then 75 mg daily or ticagrelor 180-mg loading dose then 90 mg twice daily from March 2018 to July 2020. 9 A meal decreases the AUC of the active metabolite by 57.