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Clopidogrel Cyp2c19. Carriers of CYP2C1917 have been postulated to be at decreased ischemic risk and increased bleeding risk when treated with clopidogrel. The CYP2C194 5 6 7 and 8 and other alleles may be associated with absent or reduced metabolism of Plavix but are less frequent than the CYP2C192 and 3 alleles.
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The CYP2C194 5 6 7 and 8 and other alleles may be associated with absent or reduced metabolism of Plavix but are less frequent than the CYP2C192 and 3 alleles. Warnings and Precautions Diminished Antiplatelet Activity in Patients with Impaired CYP2C19 Function. Generic Name Clopidogrel DrugBank Accession Number DB00758 Background.
CYP2C19 is involved in the formation of both the active metabolite and the 2-oxo-clopidogrel intermediate metabolite.
Warnings and Precautions Diminished Antiplatelet Activity in Patients with Impaired CYP2C19 Function. The combination use of clopidogrel and certain types of PPIs omeprazole lansoprazole esomeprazole pantoprazole increases the risk of MACE in patients with coronary artery disease. Discourage concomitant use of other known CYP2C19-inhibiting medicines with clopidogrel because these are expected to have a similar effect to omeprazole and esomeprazole CYP2C19 inhibitors. Questo metabolita รจ il derivato tiolico del clopidogrel.
