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Atorvastatin Mechanism Of Action. By preventing the conversion of HMG-CoA to mevalonate statin medications decrease cholesterol production in the liver. Inhibition of this enzyme inhibits biosynthesis of cholesterol in the liver cells.
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Mechanism of Action. Therefore LDL level in plasma reduces. Inhibits rate-limiting step in cholesterol biosynthesis by competitively inhibiting HMG-CoA reductase.
As cholesterol is important for the cellular needs and the cells are deplete of cholesterol due to inhibited synthesis LDL receptors are increasingly expressed on the cells to help promote uptake of bad cholesterol from the blood and transport it into.
Reduce cholesterol synthesis results in a compensatory increase in uptake of plasma cholesterol mediated by an increase in the number of LDL receptors. By preventing the conversion of HMG-CoA to mevalonate statin medications decrease cholesterol production in the liver. Atorvastatin also increases the number of LDL receptors on the surface of hepatic cells. Atorvastatin was patented in 1986 and approved for medical use in the United States in 1996.
