Amlodipine Toxicity. Benson BE Spyker DA Troutman WG Watson WA Bakhireva LN. Amlodipine inhibits the influx of extracellular calcium ions into myocardial and peripheral vascular smooth muscle cells thereby preventing vascular and myocardial contraction.
Cardiac toxicity results from. Concomitant use of amlodipine with strong or moderate CYP3A4 inhibitors protease inhibitors azole antifungals macrolides like erythromycin or clarithromycin verapamil or diltiazem may give rise to significant increase in amlodipine exposureThe clinical translation of these PK variations may be more. Benson BE Spyker DA Troutman WG Watson WA Bakhireva LN.
It is slightly soluble in water and sparingly soluble in ethanolNORVASC amlodipine besylate Tablets are formulated as white tablets equivalent to 25 5 and 10 mg of amlodipine for oral administration.
Benson BE Spyker DA Troutman WG Watson WA Bakhireva LN. Amlodipine besylate Norvasc is a calcium channel-blocker that is usually indicated for patients with angina pectoris due to coronary artery spasms. In order to avoid toxicity of tacrolimus administration of amlodipine in a patient treated with tacrolimus requires monitoring of tacrolimus blood levels and dose adjustment of tacrolimus when appropriate. In overdose receptor selectivity may be lost so even dihydroperidines eg.